Publications

PEER REVIEWED (book chapters and patents are found below this section)

At UConn (undergraduate students are underlined, high school students are shown in italics and underlined)

64. “Synergy between the Clavanins as a weapon against multidrug-resistant Enterobacter cloacae” Naing, M.D.; Juliano, S.; Angeles-Boza, A. M.* Submitted

63. “Improving Antimicrobial Peptides Translational Potential Through Peptidomimetics” Alfredo M Angeles-Boza*,Nuno C. Santos*,Marlon Henrique Cardoso* Front. Microbiol. – Antimicrobials, Resistance and Chemotherapy 2023, DOI: 10.3389/fmicb.2023.1304997.

62. “1,2-Azolylamidino Ruthenium(II) Complexes with dmso Ligands: Electro- and Photocatalysts for CO2 Reduction” Jennings, Murphy; Cuéllar, Elena; Rojo, Ariadna ; Ferrero, Sergio; García-Herbosa, Gabriel; Nganga, John; Angeles-Boza, Alfredo; Martín-Alvarez, Jose; Miguel, Daniel; Villafañe, Fernando* Dalton Trans. 2023 DOI: 10.1039/D3DT01122D.

61. “Hydrophobic pockets built in polymer micelles to enhance reactivity of Cu2+ ions” Wei, Zichao; Liu, Chung-Hao; Luo, Qiang; Thanneeru, Srinivas; Angeles-Boza, Alfredo; Nieh, Mu-Ping; He, Jie* Materials Chemistry Frontiers 2023, 7, 2038-2048.

60. “The Synergy Between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions” Donaghy, C.;#, Javellana, J. G.;# Hong, Y.-J.; Djoko, K.;* Angeles-Boza, A. M.* Molecules 2023, 28(5), 2156.

59. “A synthesis of preacinetobactin that enables the preparation of C5 analogs” Bray, J.; Pierce, S.; Angeles-Boza, A.; Peczuh, M.* Molecules 2022, 27(12), 3688.

58. “Metallated Anticancer Peptides: An Expanded Mechanism that Encompasses Physical and Chemical Bilayer Disruption“ Comert, F.; Heinrich, F.; Chowdhury, A.; Schoeneck, M.; Darling, C.; Anderson, K. W.; Libardo, M. D. J.; Angeles-Boza, A. M.; Silin, V.; Cotten, M. L.*; Mihailescu, M.*  Sci. Reports 2021, 11, Article number: 12620.

57. “Antimicrobial susceptibility testing of antimicrobial peptides requires new and standardized testing structures” Meurer, M.; O’Neil, D. A.; Lovie, E.; Simpson, L.; Torres, M. D. T.;  de la Fuente-Nunez, C.; Angeles-Boza, A. M.; Kleinsorgen, C.; Mercer, D. K.; von Koeckritz-Blickwede, M.* ACS Infect. Dis. 2021, 7, 2205–2208.

56. “ß-Oxochlorin cobalt(II) complexes catalyze the electrochemical reduction of CO2“ Nganga, J. K.; Chaudhri, N.; Brückner, C.;* Angeles-Boza, A. M.* Chem. Comm. 2021, 57, 4396-4399.

55. “Unraveling the implications of multiple histidine residues in the potent antimicrobial peptide Gaduscidin-1“ Portelinha, J.; Heilemann, K.; Jin, J.; Angeles-Boza, A. M.  J. Inorg. Biochem. 2021, DOI: 10.1016/j.jinorgbio.2021.111391.

54. “Methane Generation from CO2 with a Molecular Rhenium Catalyst” Nganga, J. K.; Wolf, L. M.; Mullick, K.; Reinheimer, E.; Saucedo, C.; Wilson, M. E.; Grice, K.; Ertem, M. Z.; Angeles-Boza, A. M. Inorg. Chem. 2021, 60, 3572-3584.

53. “Antimicrobial Peptides and Copper(II) Ions: Novel Therapeutic Opportunities“ Portelinha, J.†; Duay, S. S.†; Yu, S.; Heilemann, K.; Libardo, M. D. J.; Juliano, S.; Klassen, J. L.*; Angeles-Boza, A. M.* Chem. Rev. 2021, 121, 2648–2712. †Equal contributions.

52. “Nuclease activity of the peptide Gad-1 clears Pseudomonas aeruginosa biofilms under cystic fibrosis conditions” Portelinha, J.; Angeles-Boza, A. M.* ChemBioChem 2021, 22, 1646-1655.

51. “(1,2-azole)bis(bipyridyl)ruthenium(II) complexes: electrochemistry, luminescent properties, and electro- and photocatalysts for CO2 reduction” Cuéllar, E.; Pastor, L.; García-Herbosa, G.; Nganga, J.; Angeles-Boza, A. M.; Diez-Varga, A.; Torroba, T.; Martín-Alvarez, J. M.; Miguel, D.; Villafañe, F.*  Inorg. Chem. 2021, 60 (2), 692–704.

50. “Peptide-Ruthenium Conjugate as an Efficient Photosensitizer for the Inactivation of Multidrug Resistant Bacteria” Pierce, S.; Jennings, M.; Juliano, S.; Angeles-Boza, A. M. Inorg. Chem. 2020, 59 (20), 14866-14870.

49. “Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy” Mercer, D. K.*; Der Torossian Torres, M.; Duay, S. S.; Lovie, E.; Simpson, L.; von Köckritz-Blickwede, M.; de la Fuente-Nunez, C.; O’Neil, D. A.; Angeles-Boza, A. M. Frontiers in Cellular and Infection Microbiology 2020, 10, article 326.

On the news: Featured in the 2020 ACS Discovery Report: The future of antibiotics

48. “A Potent Host Defense Peptide Triggers DNA Damage and is Active against Multi-Drug Resistant Gram-Negative Pathogens” Juliano, S. A.; Serafim, L. F.; Duay, S. S.; Heredia Chavez, M.; Sharma, G.; Rooney, M.; Comert, F.; Pierce, Scott; Radulescu, A.; Cotten, M. L.; Mihailescu, M.; May, E. R.; Greenwood, A. I.; Prabhakar, R.*; Angeles-Boza, A. M.* ACS Infect. Dis. 2020, 6, 1250–1263.

47. “Enhanced antimicrobial activity of silver nanoparticles conjugated with synthetic peptide by click chemistry” Gakiya-Teruya, M.; Palomino-Marcelo, L.; Pierce, S.; Angeles-Boza, A. M.; Vijay Krishna, V.; Rodriguez-Reyes, J. C. F.* J. Nanoparticle Res. 2020, 22, Article number: 90.

46. “Antimicrobial and antibiofilm activities of helical antimicrobial peptide sequences incorporating metal-binding motifs” Agbale, C.; Sarfo, J. K.; Galyuon, I. K. ; Juliano, S.; Silva, G. G. O; Buccini, D. F. ; Cardoso, M.; Torres, M.; Angeles-Boza, A.; de la Fuente-Nunez, C.; Franco, O. Biochemistry 2019, 58 (36), 3802-3812.

45. “Molecular Dynamics Investigation into the Effect of Zinc(II) on the Structure and Membrane Interactions of the Antimicrobial Peptide Clavanin A” Duay, S.; Sharma, G.; Prabhakar, R.; Angeles-Boza, A. M.*; May, E. R.* J. Phys. Chem. B 2019, 123(15), 3163–3176.

44. “Synthetic polymers to promote cooperative Cu activity for O2 activation: Poly vs. Mono” Thanneeru, S.; Milazzo, N.; Lopes, A.; Wei, Z.; Angeles-Boza, A. M.; He, Jie* J. Am. Chem. Soc. 2019, 141 (10), 4252–4256.

43. “Direct oxygen isotope effect identifies the rate-determining step of electrocatalytic oxygen evolution reaction at a metal oxide surface” Haschke, S.; Mader, M.; Schlicht, S.; Roberts, A. M.; Angeles-Boza, A. M.;* Barth, J. A. C.;* Bachmann, J.* Nature Commun. 2018, 9(1), 4565.

Press release:Verständnis von chemischen Reaktionen der Wasserelektrolyse verbessert

42. “Phagosomal Copper–promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis” M. Libardo, D. J.; Fuente-Nunez, C.; Anand, K.; Krishnamoorthy, G.; Kaiser, P.; Pringle, S. C.; Dietz, C.; Pierce, S.; Smith, M. B.; Barczak, A. K.; Kaufmann, S. H. E.; Singh, A.; Angeles-Boza, A. M. ACS Infect. Dis. 2018, 4 (11), 1623–1634.

Press release: A Copper Bullet for Tuberculosis

 

41. “[RuII(tpy)(bpy)Cl]+-Catalyzed Reduction of Carbon Dioxide. Mechanistic Insights by Carbon-13 Kinetic Isotope Effects” Schneider, T.; Hren, M.; Ertem, M.Z.*; Angeles-Boza, A. M.* Chem. Comm. 2018, 54, 8518 – 8521.

40. “Nuclease Activity Gives an Edge to Host-Defense Peptide Piscidin 3 over Piscidin 1, Rendering it more Effective against Persisters and Biofilms” Libardo, M. J.; Bahar, A. A.; Ma, B.; Fu, R.; Zhao, J.; Nussinov, R.; Ren, D.; Angeles-Boza, A. M.*; Cotten, M. L.* FEBS J. 2017, 284, 3662-3683.

Highlighted in: http://www.aquahoy.com, https://phys.org/news

 

39. “Ullmann Reaction Catalyzed by Heterogeneous Mesoporous Copper/Manganese Oxide: A Kinetic and Mechanistic Analysis” Mullick, K.; Biswas, S.; Kim, C.; Ramprasad, R.; Angeles-Boza, A. M.*; Suib, S. L.* Inorg. Chem. 2017, 56 (17), 10290–10297. (Click here if your school does not have access to Inorganic Chemistry).

38. “Single chain polymeric nanoparticles to promote selective hydroxylation reactions of phenol catalyzed by copper” Thanneeru, S.; Duay, S.; Jin, L.; Fu, Y.; Angeles-Boza, A. M.; He, J.*  ACS Macro Letters 2017, 6, 652-656.

37. “How Does Membrane Oxidation Affect Cell Delivery and Cell Killing?“Libardo, M. D. J.; Wang, T.-Y.;  Pellois, J. P.*; Angeles-Boza, A. M.* Trends Biotech. 2017, 35, 686-690.

36. “Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines” Bartolome, Arlene P.; Villasenor, Irene M.; Lin, Yea-Lih; Libardo, M. Daben J.; Angeles-Boza, A. M.; Yang, Wen-Chin Phil. Sci. Lett. 2017, 10, 89-97.

35. “Membrane oxidation in cell delivery and cell killing applications” Wang, T.-Y.; Libardo, M. D. J.; Angeles-Boza, A. M.*;  Pellois, J. P.* ACS Chem. Biol. 2017, 12, 1170-1182.

34. “Electrochemical Reduction of CO2 Catalyzed by Re(pyridine-oxazoline)(CO)3Cl Complexes” Nganga, J. K.; Samanamu, C. R.; Tanski, J. M.; Pacheco,C.; Saucedo, C.; Batista, V. S.; Grice, K.; Ertem, M. Z.; Angeles-Boza, A. M. Inorg. Chem. 2017, 56 (6), 3214–3226.

TOC-IC

33. “Exploration of the Innate Immune System of Styela clava: Zn2+ Binding Enhances the Antimicrobial Activity of the Tunicate Peptide Clavanin A” Juliano, S. A.; Pierce, S.; deMayo, J. A.; Balunas, M. J.; Angeles-Boza, A. M.* Biochemistry 2017, 56 (10), 1403–1414.

TOC_Biochem

32. “Heterogeneous Mesoporous Manganese Oxide Catalyst for Aerobic and Additive-Free Oxidative Aromatization of N-Heterocycles” Mullick, K.; Biswas, S.; Angeles-Boza, A. M.*; Suib, S. L.* Chem. Comm., 2017, 53, 2256 – 2259.

ChemCommTOC

31. “Enzymatic” photoreduction of CO2 using metallofoldamers containing Ni-thiolate co-factors” Thanneeru, S.; Nganga, J.; Amin, A. S.; Liu, B.; Jin, L.; Angeles-Boza, A. M.;* He, J* ChemCatChem 2017, 9, 1157-1162.

Coverage: ChemViews Magazine

TOC

30. “Facile Access to Versatile Functional Groups from Alcohol by Single Multifunctional Reusable Catalyst” Biswas, S; Mullick, K.; Chen, S.-Y.; Gudz, A.; Carr, D. M.; Mendoza, C.; Angeles-Boza, A. M.; Suib, S. L. Applied Cat. B 2017, 203, 607-614.

appliedcatb

29. “Mechanism of Photocatalytic Reduction of CO2 by Re(bpy)(CO)3Cl from Differences in Carbon Isotope Discrimination” Schneider, T.; Ertem, M. Z.; Muckerman, J. T.; Angeles-Boza, A. M. ACS Catalysis 2016, 6, 5473–5481.

ACSCat_KIE-TOC

28.  “Mesoporous Copper/Manganese Oxide-Catalyzed Coupling of Alkynes: Evidence for Synergistic Cooperative Catalysis” Biswas, S; Mullick, K.; Chen, S.-Y.; Kriz, D. A.; Shakil, MD; Kuo, C.-H.; Angeles-Boza, A. M.; Rossi, A. R.; Suib, S. L. ACS Catalysis 2016, 6, 5069-5080.

ACSCat-TOC

27.  “Central Role of the Copper-binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B” Libardo, M. D. J.; Gorbatyuk, V. Y.; Angeles-Boza, A. M. ACS Infectious Diseases 2016, 2(1), 71-81.

ActualCover

 

26.  “Complementary Effects of Host Defense Peptides Piscidin 1and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities” Hayden, R. M.; Goldberg, G. K.; Ferguson, B. M.; Schoeneck, M. W.; Libardo, M. D. J.;  Mayeux, S. E; Shrestha, A.; Bogardus, K. A.; Hammer, J.; Pryshchep, S.; Lehman, H. K.; McCormick, M. L; Blazyk, J.; Angeles-Boza, A. M.; Fu, R.; Cotten, M. L.* J. Phys. Chem. B 2015, 119(49), 15235-15246.

piscidin

25.  “Hybrid peptide ATCUN-sh-Buforin: Influence of the ATCUN charge and stereochemistry on antimicrobial activity” Libardo, M. D. J.; Paul, T. J.; Prabhakar, R.; Angeles-Boza, A. M. Biochimie 2015, 113, 143-155.

Graphical Abstract

 

24. “Competitive 13C and 18O Kinetic Isotope Effects on CO2 Reduction Catalyzed by Re(bpy)(CO)3Cl” Schneider, T.; Angeles-Boza, A. M. Dalton Trans. 2015, 44, 8784-8787.

Dalton-Cover

23.  “Copper-Binding Tripeptide Motif Increases Potency of the Antimicrobial Peptide Anoplin via Reactive Oxygen Species Generation” Libardo, M. D. J.; Nagella, S.; Lugo, A.; Pierce, S.; Angeles-Boza, A. M. Biochem. Biophys. Rese. Comm. 2015, 456, 446-451.

GraphicalAbstract

22.  “Bioinorganic Chemistry of Antimicrobial and Host-Defense Peptides” Libardo, M. D. J.; Angeles-Boza, A. M. Comments on Inorganic Chemistry 2014, 34, 42-58.

GraphicalAbstract

 

21. “Improved Bioactivity of Antimicrobial Peptides by Addition of Amino-Terminal Copper and Nickel (ATCUN) Binding Motifs” Libardo, M. D.; Cervantes, J. L.; Salazar, J. C.; Angeles-Boza, A. M.* ChemMedChem 2014, 9, 1892-1901.

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Pre-UConn

1.      “Competitive Oxygen-18 Kinetic Isotope Effects Expose O−O Bond Formation in Water Oxidation Catalysis by Monomeric and Dimeric Ruthenium Complexes” Angeles-Boza, A. M.; Ertem, M. Z.; Sarma, R.; Ibanez, C. H.; Maji, S.; Llobet, A.; Cramer, C. J.; Roth, J. P. Chem. Sci. 2014, 5, 1141-1152.

2.      “Experimental and Computational Evidence of Metal-O2 Activation and Rate-Limiting Proton-Coupled Electron Transfer in a Copper Amine Oxidase” Liu, Y.; Mukherjee, A.; Ozbil, M.; Brown, D.; Angeles-Boza, A. M.; Dooley, D. M.; Prabhakar, R.; Roth, J. P. J. Phys. Chem. B 2013, 134, 218-229.

3.      “Studies of Di-iron(VI) Intermediate in Ferrate-Dependent Oxygen Evolution from Water” Sarma, R.; Angeles-Boza, A. M.; Brinkley, D. W,; Roth, J. P. J. Am. Chem. Soc. 2012, 134, 15371-15386.

4.      “Oxygen Kinetic Isotope Effects upon Catalytic Water Oxidation by a Monomeric Ruthenium Complex” Angeles-Boza, A. M.; Roth, J. P. Inorg. Chem. 2012, 51, 4722-4729.

5.      “Experimental and Computational Investigations of Oxygen Reactivity in a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase” Huff, G. S.; Doncheva, I. S.; Brinkley, D.; Angeles-Boza, A. M.; Mukherjee, A.; Cramer, C. J,; Roth, J. P. Biochemistry 2011, 50, 7375-7389.

6.      “Catalytic Mechanism of a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase” Mukherjee, A.; Angeles-Boza, A. M.; Huff, G. S.; Roth, J. P. J. Am. Chem. Soc. 2011, 133, 227-238.

7.      “Generation of Endosomolytic Reagents by Branching of Cell-Penetrating Peptides: Tools for the Delivery of Bioactive Compounds to Live Cells in Cis or Trans” Angeles-Boza, A. M.; Erazo-Oliveras, A.; Lee, Y.-J..; Pellois, J.-P. Bioconj. Chem. 2010, 21, 2164-2167.

8.      “Photophysical Properties, DNA Photocleavage, and Photocytotoxicity of a Series of Dppn Dirhodium(II,II) Complexes” Joyce, L. E.; Aguirre, J. D.; Angeles-Boza, A. M.; Chouai, A.; Fu, P. K.-L.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2010, 49, 5371-5376.

9.      “Anticancer Activity of Heteroleptic Diimine Complexes of Dirhodium: A Study of Intercalating Properties, Hydrophobicity and in cellulo Activity” Aguirre, J. D.; Angeles-Boza, A. M.; Turro, C.; Pellois, J.-P.; Dunbar, K. R. Dalton Trans. 2009 (48), 10806 – 10812.

10.  “Live Cell Cytotoxicity Studies of Dirhodium Complexes: Documentation of Antitumor Active Dirhodium Compounds Interactions with Nuclear DNA” Aguirre, J. D.; Angeles-Boza, A. M.; Chouai, A.; Pellois, J.-P.; Turro, C.; Dunbar, K. R. J. Am. Chem. Soc. 2009, 131(1), 11353-11360.

11.  “Redox-Regulated Inhibition of T7 RNA Polymerase via Establishment of Disulfide Linkages by Substituted Dppz Dirhodium(II,II) Complexes” Aguirre, J. D.; Chifotides, H. T.; Angeles-Boza, A. M.; Chouai, A.; Turro, C.; Dunbar, K. R. Inorg. Chem. 2009, 48(10), 4435-4444.

12.  “Ultrafast Ligand Exchange: Detection of a Pentacoordinate Ru(II) Intermediate and Product Formation” Liu, Y.; Turner, D. B.; Singh, T. N.; Angeles-Boza, A. M.; Chouai, A.; Dunbar, K. R.; Turro, C. J. Am. Chem. Soc. 2009, 131(1), 26-27.

13.  “Effect of Axial Coordination on the Electronic Structure and Biological Activity of Dirhodium(II,II) Complexes” Aguirre, J. D.; Lutterman, D. A.; Angeles-Boza, A. M.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2007, 46(18), 7494-7502.

14.  “Dirhodium (II,II) Complexes: Molecular Characteristics that Affect in Vitro Activity” Angeles-Boza, A. M.; Chifotides, H. T.; Aguirre, J. D.; Chouai, A.; Fu, P. K.-L.; Dunbar, K. R.; Turro, C. J. Med. Chem. 2006, 49(23), 6841-6847.

15.  “Photocytotoxicity of a New Rh2(II,II) Complex: Increase in Cytotoxicity upon Irradiation Similar to Hematoporphyrin” Angeles-Boza, A. M.; Bradley, P. M.; Fu, P. K.-L.; Shatruk, M.; Hilfiger, M.G.; Dunbar, K. R.; Turro, C. Inorg. Chem. 2005, 44(21), 7262-7264.

16.  “DNA Binding and Photocleavage in vitro by New Dppz Dirhodium(II,II) Complexes: Correlation to Cytotoxicity and Photocytotoxicity” Angeles-Boza, A. M.; Bradley, P. M.; Fu, P. K.-L.; Wicke, S. E.; Bacsa, J.; Dunbar, K. R., Turro, C. Inorg. Chem. 2004, 43(26), 8510-8519.

17.  “Direct DNA Photocleavage by a New Intercalating Dirhodium(II,II) Complex: Comparison to Rh2(μ-O2CCH3)4” Bradley, P. M.; Angeles-Boza, A. M., Dunbar, K. R., Turro, C. Inorg. Chem. 2004, 43(8), 2450-2452.

18.  “Structural Evidence for Monodentate Binding of Guanine to the Dirhodium(II,II) Core in a Manner Akin to that of Cisplatin” Chifotides, H. T.; Hess, J. S.; Angeles-Boza, A. M.; Galán-Mascarós, J. R.; Sorasaenee, K.; Dunbar, K. R. J. Chem. Soc., Dalton Trans. 2003 (23), 4426 – 4430.

19.  “Synthesis, Structures, and Conformational Characteristics of Calixarene Monoanions and Dianions” Hanna, T. A.; Liu. L.; Angeles-Boza, A. M.; Kou, X.; Gutsche, C. D.; Ejsmont, K.; Watson, W. H.; Zakharov, L. N.; Incarvito, C. D.; Rheingold, A. L. J. Am. Chem. Soc. 2003, 125(20), 6228-6238.

20.   “Inhibition of Transcription in Vitro by Anticancer Active Dirhodium(II) Complexes” Sorasaenee, K.; Fu, P. K.-L., Angeles-Boza, A. M., Dunbar, K. R., Turro, C. Inorg. Chem. 2003, 42(4), 1267-1271.

PUBLICATIONS IN SPANISH

1. “La química en nuestros platos: los preservantes” Angeles-Boza, A. M. Revista De Química 2022, 36(1), 35-41.

2. “Daniel Rabinovich: un premio a la incansable formación de estudiantes de química” Angeles-Boza, A. M. Revista De Química 2020, 34(1-2), 5-7.

3. “La importancia del uso de efectos isotópicos de átomos pesados para determinar mecanismos de reacción en la activación de moléculas pequeñas” Angeles-Boza, A. M. Revista De Química 2017, 31(1-2), 10-14.

BOOK CHAPTERS

1. “Exploring synergy and its role in antimicrobial peptide biology” Howell, M.; Wenc, A. K.; Donaghy, C. M.; Wasche, D. V.; Abissi, I.; Naing, M. D.; Pierce, S.; Angeles-Boza, A. M. in Methods in Enzymology 2022, Volume 663: Antimicrobial Peptides, Ed. Leslie Hicks.

2. “Bipyridine Ligands” Grice, K. A.; Nganga, J. K.; Naing, M. D.; Angeles-Boza, A. M.  in Comprehensive Coordination Chemistry III, Ed. Constable, E.; Parkin, G.; Que, L., Elsevier 2021. Book ISBN: 9780081026885.

PATENTS

1. “Composition And Method For Removing Metal Contaminants” Angeles-Boza, A. M.; Landis, C. R.; Shumway, W. W. PCT Int. Appl., (2009) 30 pp. Application: WO  2008-GB2972  20080902.

2. “Composition And Method For Removing Metal Contaminants” Angeles-Boza, A. M.; Landis, C. R.; Shumway, W. W. U.S. Pat. Appl. Publ.  (2009) 11 pp., Application: US  2007-849867  20070904.